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A Phase 2 randomised controlled trial published in the New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023) reported that participants receiving higher doses of retatrutide (up to 12 mg) achieved mean body weight reductions of approximately 1724% over 48 weeks
2023 Aug;25(4):454-471
Case reports have documented darkening of existing moles, new pigmented lesions, and melanoma diagnosed in users
Therefore, both doses of once-weekly semaglutide were considered dominant versus sitagliptin with more QALY benefits at lower costs
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